Figure 4 | Scientific Reports

Figure 4

From: HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver

Figure 4

Deletion of Hif-1α attenuates the nuclear accumulation of Lipin1 in CDD-treated livers. (a) Representative immunoblots of lipin1 levels in different subcellular fractions of the livers of mice fed a CDD. NC, mice fed normal chow. (b) Protein levels of lipin1 in different subcellular fractions of the livers of mice fed a CDD quantified using densitometry; n = 5–7 mice per group. *P < 0.05. (c) ChIP-qPCR analysis of lipin1 levels at the promoter of PPARα target genes in the livers of mice fed a CDD; n = 7–8 mice per group. *P < 0.05.

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