Figure 1
From: Uptake dynamics in the Lactose permease (LacY) membrane protein transporter
LacY structure and mechanism (A) The general reaction scheme of LacY galactoside/H+ symport, where a proton (step 1) and a substrate molecule (step 2) bind to a LacY state open towards the periplasm, which changes accessibility to the cytoplasm (step 3–4). Substrate release (step 5) and deprotonation (step 6) trigger reformation of the periplasmic open state (step 7–8). The simulated state is marked with a dashed box. (B) The TDG-bound LacY crystal structure (PDB ID: 4OAA) inserted into a POPE lipid bilayer and solvated by water.
