Figure 2
s1c15a4feeble mice exhibit increased inflammation of the ear following intralesional injections of IL23. Ears of WT and slc15a4feeble mice were injected every other day for 16 consecutive days with 20uL PBS containing 500 ng IL23. (A) On day 16, ears were collected for staining and measurement via H&E. (B) Ears were measured every other day with a micrometer, before injections (n = 7, 7, 6). (C) Representative H&E sections of mouse ears following treatment with IL23 (n = 7, 7, 6, 6). Images taken at 200x. Scale is the same in all pictures; scale bar = 100 µm. Data from two independent experiments each containing 6–7 mice/group. *p < 0.05, ***p < 0.0005, ****p < 0.0001 in unpaired two-sided parametric T tests.
