Figure 1 | Scientific Reports

Figure 1

From: The plasminogen binding protein PbsP is required for brain invasion by hypervirulent CC17 Group B streptococci

Figure 1

PbsP is required for virulence of CC17 GBS. (A) Western blot analysis: 10 µg of cell wall extracts from the wild-type CC17 BM110 strain (BM110) and its pbsP deletion mutant (BM110 ΔpbsP) were run on SDS-PAGE gels. Duplicate gels were stained with Coomassie (left) or blotted on nitrocellulose membranes for western blot analysis (right) using a polyclonal anti-PbsP mouse serum followed by peroxidase-conjugated goat anti-mouse IgG. (B) Effect of pbsP deletion on survival of BM110-infected mice. Adult CD1 mice were infected intravenously (i.v.) with 1 × 108 CFU of wild-type BM110 or its pbsP deletion mutant (BM110 ΔpbsP). Survival was monitored every 12 h. **p < 0.01 by Kaplan-Meier analysis. Shown are the cumulative results of two experiments, each involving 8 mice per group.

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