Figure 6 | Scientific Reports

Figure 6

From: Paraoxonase 1 knockout rats have impaired T cell development at the CD4/CD8 double-negative to double-positive transition stage

Figure 6The alternative text for this image may have been generated using AI.

PON1−/− accelerates thymocyte apoptosis via the p38 MAPK signaling pathway. (a) TUNEL assays of thymus sections from PON1+/+ and PON1−/− rats aged 2, 6 and 10 months. Scale bar = 20 μm. (b) Western blot analysis of apoptosis-associated genes in the thymus from PON1+/+ and PON1−/− rats aged 2 months. (c) Flow cytometric analysis of the percentage of indicated cells in the thymus from PON1+/+ and PON1−/− rats aged 2 months. (d) Western blot analysis the expression of p38 MAPK. CC (chelerythrine chloride): p38 MAPK activator and SB (SB203580): p38 MAPK inhibitor. (n = 3 rats per group). The experiment was repeated three times.

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