Figure 3

Spearman’s correlation between miRNA and well-known target genes in samples from normal, LGD, HGD, and EGC. (A) Negative correlation between miR-26a and EZH2 (***P = 2.87E-4, r = -0.689). Negative correlation between miR-375 and YWHAZ (*P = 1.28E−3, r = −629) and RUNX1 (*P = 3.61E−2, r = −0.432) in microarray data. (B) Negative correlation between miR-26a and EZH2 (*P = 2.18E-2, r = -0.101). Negative correlation between miR-375 and YWHAZ (P = 0.288, r = 0.028) and RUNX1 (***P = 5.00E-6, r = -0.218) observed in TCGA data. (C) Expression of miRNA and their target gene mRNA expression patterns in TCGA dataset.