Figure 6
From: Pregnancy protects the kidney from acute ischemic injury
Pregnancy effects on ischemic tolerance signaling and mitochondria functioning. The decrease in levels of GSK3β (A) and increase in levels of pGSK3β (B) thus significantly increasing pGSK3β/GSK3β ratio (C) in kidney tubular epithelial cell culture from pregnant (Preg) compared to control (Cont) animals. (D) Mitochondrial transmembrane potential measured by flow cytometry of TMRE-loaded kidney mitochondria, isolated from intact non-pregnant animals (Cont), non-pregnant (IR) and pregnant animals (Preg IR) after I/R. (E) Note that I/R causes the decrease in mean TMRE fluorescence intensity in non-pregnant animals indicating a drop of mitochondrial membrane potential, while in a group of pregnant rats such mitochondrial dysfunction was less pronounced.
