Figure 5 | Scientific Reports

Figure 5

From: Small-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogens

Figure 5

Levels of transcription of hla, psm-α, RNAIII, spa, and L17 in MRSA strain USA300 cultured in the presence of F19 (left panel) or F12 (center panel). Transcription levels of Autolysin E (AtlE) and psm-α (psma) in Methicillin-Resistant Staphylococcus epidermidis (MRSE) clinical isolate Q-15 in the presence of F19 are shown in the rightmost panel. Compound concentrations are 50 mg/L (filled bars) or 10 mg/L (open bars). Values are averages for three separate experiments; error bars indicate standard deviations; *P < 0.05. Gene expression is displayed as log2 of relative gene expression with the ribosomal protein L17 used as reference.

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