Table 5 Selected results of logistic regression association tests for EFNB3 with and without covariates.

From: Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with hypertension risks in males with hypogonadism

SNP

SNP Genotyped or Imputed

Position on Chrom 17 Build 37/hg19

Reference Allele

Alternative Allele

Minor Allele

Minor Allele Frequency

Imputation Information Score

Model with Covariates

Model without covariates

Odds Ratio

SE of Odds Ratio

P-value of Association

Odds Ratio

SE of Odds Ratio

P-value of Association

rs1641511

Genotyped

7559677

G

A

G

0.39

NA

0.914

0.076

0.23180

0.903

0.074

0.17040

rs73246870

Imputed

7559777

C

G

G

0.05

0.772

1.769

0.200

0.00441

1.752

0.198

0.00463

rs370458118

Imputed

7560153

C

CTT

CTT

0.48

0.658

0.799

0.092

0.01498

0.805

0.091

0.01626

rs61209339

Imputed

7560279

G

T

T

0.05

0.782

1.782

0.201

0.00400

1.766

0.199

0.00417

rs1050533

Imputed

7560294

C

T

T

0.50

0.580

0.886

0.098

0.21570

0.876

0.096

0.16670

rs1050540

Genotyped

7560742

C

T

T

0.09

NA

1.411

0.134

0.00993

1.370

0.132

0.01663

rs1050541

Genotyped

7560835

T

G

G

0.36

NA

1.100

0.076

0.21200

1.099

0.075

0.20460

rs1641510

Imputed

7561496

G

A

G

0.37

0.732

0.950

0.090

0.56660

0.954

0.088

0.59610

rs35899238

Imputed

7562174

T

G

G

0.06

0.678

1.228

0.194

0.28990

1.156

0.190

0.44370

rs28461213

Imputed

7562790

A

G

G

0.11

0.841

1.421

0.131

0.00737

1.362

0.129

0.01646

rs35530071

Imputed

7563124

C

CT

CT

0.09

0.612

1.747

0.168

0.00087

1.675

0.164

0.00170

rs2908807

Imputed

7563354

T

C

T

0.46

0.754

0.840

0.086

0.04288

0.845

0.085

0.04699

rs72485505

Imputed

7563826

AC

A

A

0.06

0.609

1.214

0.199

0.32890

1.144

0.194

0.48720

rs2908806

Imputed

7563827

C

A

C

0.12

0.437

1.073

0.173

0.68330

1.041

0.171

0.81530

rs12600850

Imputed

7566133

A

G

G

0.35

0.853

1.062

0.085

0.47540

1.056

0.083

0.51260

rs62062581

Imputed

7566274

T

G

G

0.27

0.928

1.029

0.087

0.74700

1.039

0.086

0.65950

rs78337160

Imputed

7566326

CT

C

C

0.26

0.931

1.028

0.087

0.74940

1.038

0.086

0.66280

rs9674772

Imputed

7566979

A

G

G

0.34

0.857

1.051

0.085

0.56190

1.045

0.084

0.60160

rs12940247

Imputed

7567703

A

G

A

0.40

0.727

0.956

0.089

0.61050

0.958

0.087

0.62400

rs34289020

Imputed

7567902

C

CT

CT

0.39

0.836

1.191

0.084

0.03700

1.178

0.082

0.04609

rs201214141

Imputed

7568712

A

G

G

0.24

0.902

1.060

0.092

0.52570

1.073

0.090

0.43360

rs55745760

Imputed

7568925

C

T

C

0.48

0.679

0.865

0.091

0.10930

0.870

0.089

0.11500

rs71159520

Imputed

7569109

C

CA

CA

0.12

0.714

1.362

0.136

0.02271

1.308

0.133

0.04371

rs8073498

Imputed

7569698

A

C

C

0.11

0.784

1.402

0.135

0.01230

1.347

0.132

0.02438

rs9893249

Imputed

7570189

T

C

C

0.11

0.783

1.401

0.135

0.01232

1.347

0.132

0.02428

rs34569991

Imputed

7570578

TA

T

TA

0.15

0.548

0.724

0.144

0.02532

0.745

0.142

0.03762

  1. Results of logistic regression association tests for SNPs located 48,843 bp to 37,942 bp 5′ upstream of the EFNB3 gene are shown. SNPs having p-values of association with hypertension below the single-gene critical Bonferroni significance level of 0.0055 for 11 LD blocks within the EFNB3 gene are in bold. SNP rs35530071 with p-value of association below the experiment-wise critical Bonferroni significance level of 0.0024 is in bold.
  2. NA: not applicable.
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