Table 6 Estimates of logistic coefficients, standard errors of estimates, Z scores and p-values of association for all terms of the genotype with covariates logistic multiple regression models for the four SNPs 5′ of the EFNB3 gene region with the lowest genotype p-values of association as produced by the R software.

SNP	Term	Coefficient	Std. Error	Z score	P-value
rs3550071	Intercept	−3.4207	0.8833	−3.873	0.000108
	Genotype	−0.5507	0.1749	−3.149	0.001639
	Age	0.0253	0.0068	3.696	0.000219
	Testosterone	−0.0019	0.0009	−2.045	0.040903
	Uric Acid	0.0020	0.0006	3.267	0.001087
	BMI	0.1285	0.0189	6.795	1.09 × 10⁻¹¹
	Heart Rate	−0.0197	0.0063	−3.125	0.001775
rs61209339	Intercept	−0.3070	0.2014	−1.525	0.127592
	Genotype	−0.1314	0.0475	−2.767	0.005741
	Age	0.0060	0.0016	3.782	0.000162
	Testosterone	−0.0004	0.0002	−2.003	0.045372
	Uric Acid	0.0005	0.0001	3.272	0.001095
	BMI	0.0293	0.0041	7.124	1.67 × 10⁻¹²
	Heart Rate	−0.0044	0.0014	−3.067	0.002205
rs73246870	Intercept	−0.3065	0.2014	−1.522	0.128348
	Genotype	−0.1298	0.0474	−2.737	0.00627
	Age	0.0060	0.0016	3.782	0.000162
	Testosterone	−0.0004	0.0002	−2.004	0.045219
	Uric Acid	0.0005	0.0001	3.272	0.001093
	BMI	0.0293	0.0041	7.125	1.67 × 10⁻¹²
	Heart Rate	−0.0044	0.0014	−3.072	0.002168
rs1050540	Intercept	−0.2959	0.2015	−1.468	0.142241
	Genotype	−0.0851	0.0324	−2.622	0.00884
	Age	0.0060	0.0016	3.789	0.000158
	Testosterone	−0.0004	0.0002	−2.037	0.041878
	Uric Acid	0.0005	0.0001	3.276	0.001079
	BMI	−0.0045	0.0014	−3.15	0.001669
	Heart Rate	0.0293	0.0041	7.124	1.68 × 10⁻¹²

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