Table 2 Global contribution of copy number variation regions (CNVRs) on asthma outcome.

Deletions	Asthmatics					Non-asthmatics					Ratio	p
Deletions	Mean	SD	Median	P25	P75	Mean	SD	Median	P25	P75	Ratio	p
CNVR count^a	12.8	11.2	10.5	8.0	14.0	14.3	18.0	10.0	8.0	14.0	0.9	0.8
Size (kb)^b	35.6	94.3	11.3	5.1	28.2	26.4	63.2	9.9	5.0	24.3	1.3	0.03
Gene count^c	1.1	2.0	1.0	0.0	2.0	0.8	1.6	1.0	0.0	1.0	1.4	0.01
Regulatory element count^d	5.1	11.6	2.0	0.0	5.0	3.9	8.7	2.0	0.0	4.0	1.3	0.03
GERP element count^e	6.1	8.1	3.9	0.5	8.0	6.5	8.6	4.2	0.7	8.7	0.9	0.1
*Duplications*
CNVR count^a	3.6	4.5	2.0	1.0	4.0	3.0	3.7	2.0	1.0	4.0	1.2	0.2
Size (kb)^b	85.1	161.2	28.1	13.6	75.8	62.1	118.3	22.9	11.2	53.1	1.4	0.05
Gene count^c	2.8	4.2	1.0	0.0	3.0	2.1	3.5	1.0	0.0	2.0	1.3	0.02
Regulatory element count^d	14.0	22.4	5.0	2.0	15.0	11.4	19.7	4.0	1.0	12.0	1.2	0.06
GERP element count^e	7.5	8.9	4.7	2.1	9.7	7.6	8.2	4.9	2.4	10.2	1.0	0.5
*Deletions* + *Duplications*
CNVR count^a	16.4	12.4	13.0	10.0	18.0	17.3	18.4	13.0	10.0	18.0	1.0	0.5
Size (kb)^b	43.0	108.4	13.0	5.8	32.9	31.6	74.8	11.4	5.5	28.9	1.4	5 × 10⁻³
Gene count^c	1.4	2.7	1.0	0.0	2.0	1.0	2.1	1.0	0.0	1.0	1.4	2 × 10⁻⁴
Regulatory element count^d	6.8	14.8	2.0	0.0	7.0	5.0	11.5	2.0	0.0	5.0	1.4	7 × 10⁻⁴
GERP element count^e	6.3	8.3	4.0	0.7	8.3	6.6	8.5	4.3	1.0	8.9	1.0	0.1

Asthmatic and non-asthmatic children from Salvador-SCAALA were compared in terms of: ^acount of CNVRs per individual; ^bestimated size of CNVRs (kb, kilobase); ^cnumber of genes captured by CNVR; ^dnumber of regulatory elements captured by CNVR; ^enumber of GERP constrained elements captured by CNVR.
SD: standard deviation; P25: 25% percentile; P75: 75% percentile; Ratio: case/ctrl ratio (mean); p values ≤ 0.05 were considered statistically significant [Mann-Whitney U test (two-sided)].

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