Figure 3 | Scientific Reports

Figure 3

From: Feasibility and robustness of dynamic 18F-FET PET based tracer kinetic models applied to patients with recurrent high-grade glioma prior to carbon ion irradiation

Figure 3

Goodness-of-fit in patient data from fits with different compartment models. The top two plots show the measured time-activity-curve in two exemplary voxels (dots) together with fitted curves from the 1TCM, standard 1TCM and 2TCM (lines). The 2TCM curve visually best describes the measured data points. Differences between s1TCM and 1TCM appear to be small. The bottom plot shows the distribution of the fit-quality measure reduced X² from all three models in every patient. Note that values for \({{\chi }^{2}}_{red}\) are shown on a logarithmic scale, since s1TCM yields much higher \({{\chi }^{2}}_{red}\,\)than 1TCM and 2TCM. Lower values of \({{\chi }^{2}}_{red}\) indicate better fits, i.e. less deviation between model curve and data points. Fits from s1TCM yield significantly higher \({{\chi }^{2}}_{red}\,\), thus poorest fits. \({{\chi }^{2}}_{red}\) from the 1TCM and 2TCM yield similar values, however 1TCM appears to present with slightly better fits.

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