Figure 4
Unique grouping of gene expression patterns in KD patients. (Left) Heat map of the top 100 genes that were significantly differentially expressed between acute and convalescent phases in KD patients who were not in clusters, adjusted for illness day of acute blood sample collected on days 2–10 after fever onset. Rows represent 100 genes and columns represent 118 acute phase patient samples. Each cell value represents the intensity of mRNA expression in log-scale. Two patient phenotypes, age and GGT values, are displayed at the top. Annotation at top: Horizontal line is median age (2.8 yrs.), High GGT = > 3 SD above upper limit of normal for age reference range (Right). Demographic and clinical characteristics associated with 118 KD patients grouped based on unsupervised clustering of gene expression patterns. Clinical laboratory data were obtained before treatment with IVIG and at the same phlebotomy as the acute samples for gene expression. Values are median and IQR except those marked with *, which are ratios. Comparisons by Mann-Whitney test for continuous variables, and a χ2 test for proportions. (A larger version of the heat map is included in the Supplementary Information).
