Table 1 Characteristics of Included Studies.
From: Effect of statins on experimental postoperative adhesion: a systematic review and meta-analysis
First author, publication year, | Animal | Surgery | Group | Definition |
|---|---|---|---|---|
Javaherzadeh, 2016 | Male Wistar albino rats | Laparotomy (cecum) | Control | N/S |
Experimental | N/S + Simvastatin (30 mg/kg) | |||
Yilmaz, 2009 | Non-pregnant, female Wistar albino rats | Laparotomy (uterine horns) | Control | No treatment |
Low dose atorvastatin | 2.5 mg/kg/day atorvastatin | |||
High dose atorvastatin | 30 mg/kg/day atorvastatin | |||
Metformin | 50 mg/kg/day metformin | |||
Lalountas, 2012 | Male Wistar rats | Laparotomy (caecum) | No film | No treatment |
Placebo | Carboxymethylcellulose film without atorvastatin | |||
Low-dose group | Statofilm containing 0·125 mg/kg atorvastatin | |||
High-dose group | Statofilm containing 1 mg/kg atorvastatin | |||
Lalountas, 2010 | Male Wistar rats | Laparotomy (cecum) | Group 1 | No treatment |
Group 2 | Atorvastatin 30 mg/kg | |||
Group 3 | HA/CMC membrane | |||
Group 4 | HA/CMC membrane + Atorvastatin 30 mg/kg | |||
Sun, 2015 | Male Sprague-Dawley rats | Laminectomy | Control | No treatment |
Chitosan | Chitosan | |||
Simvastatin | Simvastatin (1 mg/ml) | |||
Aaron, 2007 | Male Wistar rats | Laparotomy (caecum) | Control | Control |
Lovastatin | Lovastatin (30 mg/kg) | |||
Atrovastatin | Atorvastatin (30 mg/kg) | |||
Kucuk, 2007 | Male Wistar rats | Laparotomy (caecum) | Group 1 | Simvastatin 0.57 mg/kg/day injected intraperitoneally right after operation and 5 day after |
Group 2 | Simvastatin 0.57 mg/kg/day injected via gavage right after operation and 5 day after | |||
Group 3 | N/S | |||
Wu, 2016 | Male Sprague-Dawley rats | Femoral condyle exposing surgery | saline control group | Gelatin sponges soaked with N/S |
ROS 10 mg/kg group | Gelatin sponges soaked with 10 mg/kg of rosuvastatin | |||
ROS 20 mg/kg group | Gelatin sponges soaked with 20 mg/kg of rosuvastatin | |||
Gűrer, 2015 | Male Wistar rats | Laminectomy | Group 1 | Laminectomy |
Group 2 | Spongostan | |||
Group 3 | Spongostan soaked with 20 mg/Kg rosuvastatin | |||
Group 4 | Systemic 20 mg/Kg rosuvastatin |
