Figure 6 | Scientific Reports

Figure 6

From: Exosomes from normal and diabetic human corneolimbal keratocytes differentially regulate migration, proliferation and marker expression of limbal epithelial cells

Figure 6The alternative text for this image may have been generated using AI.

Effect of N- or DM-Exos on LESC marker expression in normal organ-cultured corneas and primary LEC. (a) Normal Exo treatment in normal organ-cultured corneas led to increased expression of putative LESC markers, K15 and FZ7, and no significant change in K17 protein level compared to fellow corneas treated with DM-Exos (immunofluorescent staining of limbal corneal sections). The same exposure time was used for each set of compared stained sections, and the assessment was done by more than one observer. (b) Western analysis shows that N-Exos treatment increased, whereas DM-Exo treatment decreased K17 protein expression level in primary LEC compared to control treated cells, which did not reach significance. Antibody to β-actin was used as equal loading control and for semi-quantitation.

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