Table 1 Breakpoints used for susceptibility testing of Salmonella species.

From: Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials

Class

Agent

Range (mg/L)

nWTa

Clinical Breakpointb

CS

CR

Aminoglycosides

Gentamicin

0.25–16

2

≤4

>8

Streptomycin

2–64

16

≤32

>32

β-lactam/β-lactam inhibitor combination

Amoxicillin-Clavulanate (2:1 ratio)

1–32

≤8

>16

Cephems

Cefoxitin

0.5–32

8

≤8

>16

Ceftiofur

0.12–8

2

— 

Ceftriaxone

0.25–64

≤1

≥4

Fluoroquinolones

Ciprofloxacin

0.015–4

0.06

≤0.06

>0.5

Quinolones

Nalidixic acid

0.5–16

Folate pathway inhibitors

Trimethoprim-Sulfamethoxazole (1:19)

0.12–4

1

≤2

>2

Macrolides

Azithromycin

0.12–16

Penicillins

Ampicillin

1–32

8

≤8

>16

Phenicols

Chloramphenicol

2–32

16

≤8

>16

Tetracyclines

Tetracycline

4–32

8

≤4

>8

  1. anWT = non-wild type [EUCAST epidemiological cut-off values (mg/L) (ECOFF)].
  2. bCLSI VETO1S,(CLSI, 2015) or M100S(CLSI, 2016) breakpoints (mg/L), CS = Clinically-sensitive; CI = Clinically-Intermediate (between CS and CR, not shown); CR = Clinically-resistant.
  3. “—” Not defined.