Table 1 Baseline characteristics with regard to CTLA-4 rs231775 genotypes.
Parameter | All (n = 644) | rs231775 | p value | |
|---|---|---|---|---|
GG (n = 101) | AA/AG (n = 543) | |||
Age, years | 63 ± 15 | 63 ± 14 | 63 ± 15 | 0.5354 |
Male [%] | 66 | 62 | 67 | 0.3829 |
Body mass index (BMI) | 28 ± 6 | 29 ± 7 | 27 ± 6 | 0.0365 |
Severity of sepsis | ||||
Septic shock, % | 51 | 50 | 52 | 0.6786 |
Sequential Organ Failure Assessment (SOFA) score | 9.4 ± 3.9 | 9.8 ± 3.9 | 9.3 ± 3.9 | 0.3057 |
Acute Physiology and Chronic Health Evaluation (APACHE II) score | 22 ± 7 | 22 ± 7 | 22 ± 7 | 0.5020 |
Comorbidities, n [%] | ||||
Hypertension | 54 | 54 | 54 | 0.9540 |
History of myocardial infarction | 5 | 6 | 2 | 0.0954 |
Chronic obstructive pulmonary disease | 15 | 15 | 15 | 0.9486 |
Renal dysfunction | 10 | 11 | 10 | 0.8613 |
Noninsulin-dependent diabetes mellitus | 9 | 11 | 8 | 0.4318 |
Insulin-dependent diabetes mellitus | 11 | 14 | 10 | 0.2396 |
Chronic liver disease | 6 | 11 | 6 | 0.0425 |
History of cancer | 16 | 13 | 16 | 0.4221 |
History of stroke | 6 | 6 | 6 | 0.9852 |
Recent surgical history, n [%] | ||||
Elective surgery | 29 | 25 | 30 | |
Emergency surgery | 53 | 57 | 52 | |
No history of surgery | 18 | 18 | 18 | |
Site of infection, n [%] | ||||
Lung | 62 | 63 | 62 | |
Abdomen | 20 | 22 | 20 | |
Bone or soft tissue | 4 | 4 | 4 | |
Surgical wound | 2 | 2 | 1 | |
Urogenital | 2 | 1 | 3 | |
Primary bacteremia | 7 | 3 | 7 | |
Other | 3 | 5 | 3 | |
Organ support [%] | ||||
Used during observation period | ||||
Mechanical ventilation | 93 | 95 | 93 | 0.4491 |
Use of vasopressor | 79 | 81 | 79 | 0.5906 |
Renal replacement therapy | 21 | 27 | 20 | 0.1102 |
Used on sepsis onset | ||||
Mechanical ventilation | 86 | 88 | 85 | 0.4520 |
Use of vasopressor | 67 | 70 | 66 | 0.3928 |
Renal replacement therapy | 9 | 14 | 8 | 0.0535 |
Use of statins [%] | 24 | 23 | 24 | 0.7999 |
ICU length of stay | 20 ± 16 | 19 ± 12 | 21 ± 17 | 0.5142 |
