Figure 6
From: Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Results of the MMP3 ELISA. (A) A total of 24 serum samples from no-rejection (n = 13), nonsevere rejection (n = 5) and severe rejection (n = 6) groups were included in ELISA validation of the SOMAscan results. Serum samples taken at time-points of severe rejections showed significantly higher levels of MMP3 as compared to samples from no-rejection (p = 0.0009) and nonsevere rejection (p = 0.0173) time-points. Data is presented as boxplots: Boxes delineate 1st (lower border) and 3rd (upper border) quartiles from the median (line within the box); whiskers represent minimum and maximum values. Statistical significance was evaluated with a two-tailed non-parametric Mann-Whitney test. (B) ROC curves of the MMP3 ELISA data between the no-rejection, nonsevere rejection and severe rejection samples. MMP3 shows good performance as diagnostic marker for severe rejection episodes as compared to no-rejection (AUC = 0.9487; 95% CI 0.8409 to 1) as well as nonsevere rejection (AUC = 0.9333; 95% CI 0.7797 to 1) episodes. n.s., not significant; ROC, receiver operating characteristic.
