Figure 1 | Scientific Reports

Figure 1

From: Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survival

Figure 1

IDH1 wildtype status positively correlates with tumour stem cell properties. (A) The risk of seizures at onset is associated with IDH1 R132H mutations (*p < 0.05, chi2-test). (B,C) Distribution of WHO grade (B) and IDH mutation status (C) in glioma with high and low nestin expression (above and below median, *p < 0.05, chi2-test). (D) Seizures at onset in tumours with nestin expression above and below median (*p < 0.05, chi2-test). (E,F) Representative images illustrating lineage-restricted progenitor cell-like (to the left, R47) and neurosphere-like growth (to the right, R28, 25-fold magnification each). IDH mutation status correlates with the ability to form neurospheres. (***p < 0.0002, chi2-test). (G) The differentiation pattern of first-passage tumour cell cultures of three gliomas with IDH R132H (R26, R24, R42) mutations and four IDH wildtype gliomas (R11, R18, R22, R28) are given (**p = 0.0004, *p = 0.005, two-sided student’s t-test).

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