Figure 3 | Scientific Reports

Figure 3

From: Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survival

Figure 3

Synapse-like structures within GSC lines. (A) DAPI, synaptophysin (high and low magnification), phasecontrast and β-III tubulin staining of GSC line R28 is shown. (B) Number of synaptophysin-positive cell-cell contacts under standard culture conditions (serum free medium supplemented with EGF/FGF/B27) and under conditions favoring neuronal differentiation (no growth factors, 1% serum, 0.1% retinoic acid, p < 0.005, student’s-t-test). (C) Electronmicroscopy of GSC spheres cultured under standard conditions. Synapse-like structures are shown in higher magnification on the right side.

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