Figure 4 | Scientific Reports

Figure 4

From: Aberrant neuronal differentiation is common in glioma but is associated neither with epileptic seizures nor with better survival

Figure 4

Synapse-like structures in vivo. (A) Immunostaining detecting human synaptophysin in xenograft tumours (R8, R28). (B) Synaptophysin immunostaining (left side) and IDH1 immunostaining (right side) of a tissue microarray containing WHO grade 2 tumours (2) and WHO grade 3 tumour (3), cerebellum as positive control (C), and intestine as negative control (IT) for the synaptophysin staining. (C) Representative synaptophysin immunostaining of human IDH wildtype glioblastoma samples with high (left) and low synaptophysin expression (right). (D) Correlation of synaptophysin expression with markers indicative for proneural (proneural-mesenchymal score >0) and the mesenchymal subtype (proneural-mesenchymal score <0, Pearson r = 0.3, p = 0.05). (E) Association of epileptic seizures and markers indicative for proneural (proneural-mesenchymal score >0) and the mesenchymal subtype (proneural-mesenchymal score <0 (p = 0.3, Mann-Whitney U-test). (F) Association of synaptophysin expression with epileptic seizures (p = 0.9, Mann-Whitney U-test).

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