Figure 1 | Scientific Reports

Figure 1

From: Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes

Figure 1

Schematic representation of the proposed mechanisms underlying diabetic cardiomyopathy in relation to sodium-glucose co-transporter (SGLT). Upregulation of SGLT in cardiomyocytes in the presence of diabetes mellitus results in an increase in sodium influx into cardiomyocytes that in turn increases cytosolic calcium loading via the sodium-calcium exchanger (NCX). Intracellular calcium overload can lead to (1) delayed after depolarizations (DADs), triggers for tachycardia, (2) impaired excitation-contraction coupling, and (3) activation of calcium-sensitive signaling pathways, leading to pathological changes.

Back to article page