Figure 3
Steric clashes (c red) introduced upon mutation in alr when Glu373 (a,b accessible surface area: 188.42 Å2) was mutated to Gly (c accessible surface area: 89.41 Å2). (d) D-Cycloserine(DCS)- pyridoxal 5′-phosphate (PLP) interaction with Y388 at the alanine racemase active site. Lys66, the original residue interacting with PLP, shown in olive green. Mutations labelled according to property: ligand affinity (pink), protein-protein interactions (teal), protomer stability (blue) and unclassified (charcoal grey).
