Figure 4 | Scientific Reports

Figure 4

From: Morphological changes, nitric oxide production, and phagocytosis are triggered in vitro in microglia by bloodstream forms of Trypanosoma brucei

Figure 4

Ultrastructural analysis of CD45int/CD11bhigh/eGFP+ microglia. (a) Typical morphology of control microglia. (b–f) Main ultrastructural changes observed in CD45int/CD11bhigh/eGFP+ cells after 6 h of co-incubation with trypanosomes at 37 °C. Note alterations in the nucleus/cytoplasm ratio in B with respect to A. Abbreviations: Nucleus (N), cytoplasmic protrusions (CP), multivesicular bodies (MVB), endoplasmic reticulum (ER), myelin-like structures (ML), vacuoles (V). Bars in A and B represent 2.5 µm; bars in C-F denote 0.5 µm.

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