Figure 1
From: TRSP is dispensable for the Plasmodium pre-erythrocytic phase
Homing of trsp knockout sporozoites to the liver. (A,C,E,G) Representative pictures of C57BL/6 mice injected intravenously with 1.5 × 105 luciferase-expressing control or TRSP- I21 (A,C) or I26 (E,G) sporozoites collected from mosquito salivary glands. Quantification of the signal in percentage of total flux (photons/s) in the liver versus total body signal (mean ± SD; n = 3), determined 7 minutes (A,E) or 2–4 hours (C,G) after sporozoite injection. (B,D,F,H) Bioluminescent signal in the liver plotted as average radiance (photons/s/cm2/sr; mean ± SD; n = 3) of the mice infected with TRSP- I21 (B,D) or I26 (F,H) sporozoites 7 minutes (B,F) or 2–4 hours (D,H) post-infection. Data shown is representative of two independent experiments. Statistical analysis was performed using the Mann Whitney test: n.s., non-significant.
