Figure 4 | Scientific Reports

Figure 4

From: Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI

Figure 4

Summary of changes in quantitative, non-invasive MRI parameters, as a function of Ixazomib dose (8, 9.5 and 11 mg kg−1), at 72 hours post-dosing. Only CEST measurements associated with amines and amide groups show a correspondence with Ixazomib dose. Significant increases, in a dose-dependent manner, were observed in amine and amide peak areas from CEST MRI measurements. Tumor apparent diffusion coefficient (ADC) also increased significantly for the two highest doses, and T2 decreased significantly in LS174T tumors only (the top and bottom set of asterisks or crosses represents LS174T and LS174T, respectively, where two mean values overlap). Data points are mean ± standard error; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (two-way ANOVA); *compared to baseline, ^compared to measurement at 24 hours post-Ixazomib dose, +compared to control.

Back to article page