Table 1 Characteristics of the study group by eGFR level.

From: Association between circulating tumor necrosis factor-related biomarkers and estimated glomerular filtration rate in type 2 diabetes

Characteristic

All

eGFR ≥ 60

eGFR 30–59

P  a

(N = 594)

(n = 402)

(n = 192)

eGFR (mL/min/1.73 m2)

69 (56, 84)

80 (69, 92)

48 (43, 55)

 

ACR (mg/g·Cr)

22 (9, 123)

18.5 (8.0, 58.3)

66 (13, 360)

<0.001

Normo (%)

56.2

63.7

40.6

<0.001

Micro (%)

28.8

27.6

31.3

Macro (%)

15.0

8.7

28.1

Age (yr)

65 ± 13

62 ± 13

71 ± 10

<0.001

Male sex (%)

55.4

52.0

62.5

0.01

BMI (kg/m2)

25.1 ± 4.6

25.3 ± 4.9

24.7 ± 3.9

0.13

Sys BP (mmHg)

139 ± 17

138 ± 16

141 ± 20

0.13

UA (mg/dL)

5.4 ± 1.3

5.0 ± 1.3

6.0 ± 1.3

<0.001

HDL-C (mg/dL)

52 ± 13

53 ± 13

50 ± 13

0.007

Non-HDL-C (mg/dL)

130 ± 32

131 ± 33

127 ± 32

0.12

Hemoglobin (g/dL)

13.6 ± 1.7

13.9 ± 1.6

12.9 ± 1.7

<0.001

HbA1c (%)

7.3 ± 1.2

7.4 ± 1.2

7.2 ± 1.1

0.03

CRP (mg/dL)

0.11 (0.06, 0.19)

0.10 (0.06, 0.19)

0.11 (0.07, 0.19)

0.28

TNF-related biomarkers

TNFα (pg/mL)

12.6 (9.5, 18.3)

11.1 (8.8, 15.8)

15.9 (12.2, 21.5)

<0.001

PGRN (ng/mL)

56 (49, 65)

55 (47, 63)

60 (52, 67)

<0.001

TNFR1 (pg/mL)

1562 (1263, 2016)

1384 (1169, 1691)

2149 (1695, 2627)

<0.001

TNFR2 (pg/mL)

3339 (2717, 4297)

2972 (2535, 3610)

4337 (3696, 5635)

<0.001

  1. aeGFR ≥60 vs. eGFR 30–59. Data are mean ± SD, median (quartiles), or %.ACR, the ratio of urinary albumin to creatinine; BMI, body mass index; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; Micro, microalbuminuria; Normo, noromoalbuminuria; PGRN, progranulin; Macro, macroalbuminuria; SD, standard deviation; Sys BP, systolic blood pressure; TNFR, TNF receptor; UA, uric acid.
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