Figure 2
From: LncRNA BLAT1 is Upregulated in Basal-like Breast Cancer through Epigenetic Modifications
BLAT1 Expression in Pan-Cancers and Breast Cancer Cell Lines, and In Silico Analysis. (A) BLAT1 expression was analyzed using Pan-Cancer RNA-seq datasets. The values are presented as log2 (FPKM + 1). ACC, Adrenocortical Carcinoma; BLCA, Bladder Urothelial Carcinoma; BRCA, Breast Invasive Carcinoma; CESC, Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma; CHOL, Cholangiocarcinoma; COAD, Colon Adenocarcinoma; DLBC, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; ESCA, Esophageal Carcinoma; GBM, Glioblastoma Multiforme; HNSC, Head and Neck Squamous Cell Carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney Renal Clear Cell Carcinoma; KIRP, Kidney Renal Papillary Cell Carcinoma; LAML, Acute Myeloid Leukemia; LGG, Brain Lower Grade Glioma; LIHC, Liver Hepatocellular Carcinoma; LUAD, Lung Adenocarcinoma; LUSC, Lung Squamous Cell Carcinoma; MESO, Mesothelioma; OV, Ovarian Serous Cystadenocarcinoma; PAAD, Pancreatic Adenocarcinoma, PCPG, Pheochromocytoma and Paraganglioma; PRAD, Prostate Adenocarcinoma; READ, Rectum Adenocarcinoma; SARC, Sarcoma; SKCM, Skin Cutaneous Melanoma; STAD, Stomach Adenocarcinoma; TGCT, Testicular Germ Cell Tumors; THCA, Thyroid Carcinoma; THYM, Thymoma; UCEC, Uterine Corpus Endometrial Carcinoma; UCS, Uterine Carcinosarcoma; UVM, Uveal Melanoma. (B) Expression of BLAT1 was analyzed in twenty beast cell lines by qRT-PCR relative to the expression in non-malignant breast cells (184A1 and HMEC). HCC-1569 and MDA-MB-468 cells showed the highest expression among twenty cell lines. (C) UCSC genome browser view of 2q14.2 (hg19) shows the close location (within 7 Kb) of BLAT1 (RP-11-19E11.1) and EN1. BLAT1 has a rich epigenetic landscape (ChIP-seq data from ENCODE) and CpG islands in the regulatory region.
