Table 1 Types of p53-binding protein1 (53BP1) expression in urothelial tumors.

From: Expression pattern of p53-binding protein 1 as a new molecular indicator of genomic instability in bladder urothelial carcinoma

 

Type of 53BP1 expression in all nuclei (%)

Ki-67-positive

nuclei

Type of 53BP1 expression in Ki-67-positive nuclei (%)

 

n

Total

nuclei

Stable

Low DDR

High DDR

Diffuse

LF

Stable

Low DDR

High DDR

Diffuse

LF

Normal

10

3612

1606

(44.5%)

1096

(30.3%)

834

(23.1%)

31

(0.9%)

45

(1.3%)

226

(6.3%)

127

(3.5%)

44

(1.2%)

51

(1.4%)

4

(0.1%)

0

UP

10

4876

1544

(31.7%)

1881

(38.6%)

1378

(28.3%)

9

(0.2%)

64

(1.3%)

94

(1.9%)

56

(1.1%)

22

(0.5%)

16

(0.3%)

0

0

LGUC

10

4340

1814

(41.8%)

709

(16.3%)

728

(16.8%)

1049

(24.2%)

40

(0.9%)

295

(6.8%)

190

(4.3%)

32

(0.7%)

29

(0.7%)

40

(0.9%)

4

(0.1%)

HGUC

10

3810

2087

(54.8%)

213

(5.6%)

211

(5.5%)

1146

(30.0%)

153

(4.0%)

1152

(30.2%)

635

(16.7%)

84

(2.2%)

146

(3.8%)

235

(6.2%)

52

(1.4%)

p value

p < 0.0001†

 

p < 0.0001†

  1. †Jonckheere-Terpstra test. DDR, DNA damage response; LF, large foci; Normal, normal urothelium; UP, urothelial papilloma; LGUC, low grade urothelial carcinoma; HGUC, high grade urothelial carcinoma.
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