Table 3 Association between 53BP1 expression type and chromosomal instability in urothelial cells.

From: Expression pattern of p53-binding protein 1 as a new molecular indicator of genomic instability in bladder urothelial carcinoma

Level of chromosomal instability

Number of nuclei

Type of 53BP1 expression

Stable

Low DDR

High DDR

Diffuse

LF

0

4966

1890

(38.1%)

1552

(31.3)

1427

(28.7)

10

(0.2%)

87

(1.8%)

1

5897

2293

(38.9%)

1830

(31.0%)

1141

(19.4%)

583

(9.9%)

50

(0.9%)

2

1984

890

(44.9%)

188

(9.5%)

262

(13.2%)

634

(32.0%)

10

(0.5%)

3

2179

1122

(51.5%)

253

(11.6%)

262

(12.0%)

393

(18.0%)

149

(6.8%)

4

1612

856

(53.1%)

76

(4.71)

59

(3.7%)

615

(38.2%)

6

(0.4%)

 

p < 0.0001†

  1. †Jonckheere-Terpstra test; DDR, DNA damage response; LF, large foci.