Figure 3
From: Characterization of the miRNA regulators of the human ovulatory cascade
The resultant DE miRNAs were analyzed through the use of IPA (Ingenuity Pathway Analysis, QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis)19 to explore the inversely correlated miRNA-regulated pathways and mRNA expression in preovulatory granulosa cells. This analysis revealed that both (A) miR-21 and (B) let-7 are involved in the downregulation of several important genes. (C) Putative crosstalk between the FOXM1 signaling pathway and miR-21 signaling. A number of genes and pathways are reciprocally regulated by these negatively correlated transcription regulators. mir-21 expression is upregulated, whereas FOXM1 expression is downregulated during the ovulatory process.
