Table 2 The 234 miRNA target genes that negatively correlated with the expression of 22 differentially expressed miRNAs.

hsa-let-7g-5p

let-7a-5p (and other miRNAs w/seed GAGGUAG)

40

ADAMTS15, ANGPTL2, AURKB, B3GAT1, C15orf39, CDC25A, CHRD, CMTM6, DAPK1, DSP, ESPL1, ESR2, ETNK2, EZH2, FANCD2, FRMD4B, GAS7, GATM, IFNLR1, KIF21B, LINGO1, MMP11, MYO5B, MYRIP, NEMP1, NOS1, PAG1, PARM1, PLXNC1, PPT2, PRIM1, RBM38, RIMS3, RRM2, SLC1A4, SLC37A4, THBS1, TMPO, TYMS, UNC5A

hsa-miR-107

miR-103-3p (and other miRNAs w/seed GCAGCAU)

26

ADGRB3, AJUBA, BCL11A, CDCA4, CLSPN, ESR1, HOXD10, HSDL1, IGSF3, IHH, LRP1, MBOAT1, NAV1, NEIL1, NOS1, NRP2, OLFM1, PAG1, RIMS3, RNF19A, RTKN2, S1PR3, SOWAHC, SYNDIG1, TMEM35, WHSC1

hsa-miR-125b-5p

miR-125b-5p (and other miRNAs w/seed CCCUGAG)

29

ADAMTS15, AJUBA, C15orf39, CACNB2, CDC25A, ENTPD1, FAM78A, GLB1L2, HAPLN1, HCN1, HCN4, HOXD9, KCNH3, KCNIP3, LOXL1, MMP11, NEMP1, NUP210, OPALIN, PARM1, PPT2, PRSS35, RBM38, SLC4A8, ST6GAL1, STMN3, TMCC2, TNFSF4, VEGFA

hsa-miR-130a-3p

miR-130a-3p (and other miRNAs w/seed AGUGCAA)

32

ADAMTS18, ADCY2, ADGRB3, ARX, BCL11A, CEP55, CHST1, DEPDC1, DIAPH3, ESCO2, ESR1, FAM78A, GSE1, HES1, IGSF3, INHBB, ITPKB, KLHDC8A, SIK1, MB21D2, MTCL1, MYO1D, NRP2, PLCL2, PLLP, PRR15, RALGAPA2, SHANK2, SOX4, SOX5, ST8SIA5, ZEB1

hsa-miR-132-3p

miR-132-3p (and other miRNAs w/seed AACAGUC)

12

ARX, COL4A4, HAPLN1, HUNK, ITPKB, KIF21B, OLFM1, PALM2, RAP2B, SHANK2, SOX4, SOX5

hsa-miR-424-5p

miR-16-5p (and other miRNAs w/seed AGCAGCA)

39

ADAMTS18, C14orf37, CASR, CD47, CDC25A, CDCA4, CHEK1, CLSPN, CRHBP, DPH5, GLCE, GSE1, HCN1, HERC6, IHH, LY6E, MARCH4, MCF2L, MSH2, MYO5B, MYRIP, NAV1, NOS1, NRP2, NUP210, PAG1, PARM1, PLXNA2, PPIF, PPT2, PRIM1, RIMS3, SLC4A8, SOWAHC, SOX5, SYNDIG1, VEGFA, WHSC1, ZNF423

hsa-miR-20a-5p

miR-17-5p (and other miRNAs w/seed AAAGUGC)

36

AJUBA, CDC25A, CEP128, CHAF1A, CNNM3, DDIAS, DPF3, E2F1, ELAVL2, ESR1, FRMD4B, GUCY1A3, HAUS8, HCN4, ITPKB, SIK1, MARCH4, MCF2L, MCM3, MYLIP, MYO1D, MYO5B, NR4A3, NRP2, PBK, POLQ, PRR15, RASL11B, RRM2, SEMA7A, SHANK2, SORL1, SOWAHC, SOX4, VEGFA, WHSC1

hsa-miR-181a-5p

miR-181a-5p (and other miRNAs w/seed ACAUUCA)

35

ACAN, ADAMTS18, ADGRB3, ATP1B1, ELAVL2, ERG, ESR1, FAM19A2, GAL3ST3, GAS7, GREM1, GSE1, HAPLN1, HCN1, HEY2, HMGB2, MB21D2, MBOAT1, MTCL1, NR4A3, PAG1, PALM2, PARM1, PEG3, PLCL2, POLQ, PPP1R12B, RALGAPA2, RFTN2, RTKN2, SFRP4, SOX5, THBS2, UNC5A, WHSC1

hsa-miR-191-5p

miR-191-5p (and other miRNAs w/seed AACGGAA)

2

BCL11A, SOX4

hsa-miR-19b-3p

miR-19b-3p (and other miRNAs w/seed GUGCAAA)

36

ARHGAP11A, CEP55, CHST1, DAAM1, DAG1, EDARADD, ELAVL2, ENC1, ESR1, IFI44L, IGSF3, INHBB, ITPKB, PCLAF, MATN2, MATN3, MB21D2, MTCL1, MYLIP, NAV1, NRP2, PARM1, PLCL2, PLXNC1, PRC1, RAP2B, RNF19A, SHANK2, SOGA1, SORL1, SOX4, SOX5, SPTSSB, SYNPO2, THBS1

hsa-miR-21-5p

miR-21-5p (and other miRNAs w/seed AGCUUAU)

9

BCL11A, CDC25A, DAG1, ERG, MATN2, MSH2, PAG1, SOX5, ST6GAL1

hsa-miR-22-3p

miR-22-3p (miRNAs w/seed AGCUGCC)

10

ADCK2, CHGA, DERL3, EMILIN3, ESR1, GATM, HUNK, NUSAP1, RAPGEF3, VIT

hsa-miR-223-3p

miR-223-3p (miRNAs w/seed GUCAGUU)

14

ADGRB3, ATP1B1, CSPG5, CTSV, E2F1, ECT2, GALNT18, LAYN, MYO5B, NUP210, OLFM1, RIMS3, STMN1, ZEB1

hsa-miR-23b-3p

miR-23a-3p (and other miRNAs w/seed UCACAUU)

41

ARHGEF6, BCL11A, CDC6, COL4A4, DAPK1, DDAH1, DEPDC1, DTL, EDARADD, ENC1, EXOC3L4, FANCI, FSHR, GALNT12, GLCE, GREM1, HAPLN1, HES1, HMGB2, HOXD10, IHH, KCNIP4, MAP7D2, MKX, NDC1, NEMP1, PDGFA, PLXNC1, PPIF, PRSS35, RAD51AP1, RAP2B, SFRP4, SOWAHC, SPTSSB, SYNPO2, TMPO, TOP2A, WHSC1, ZEB1, ZNF423

hsa-miR-29a-3p

miR-29b-3p (and other miRNAs w/seed AGCACCA)

29

ADAMTS18, ADAMTS2, ADCYAP1R1, AGPAT4, ATP1B1, AUNIP, BCL11A, CLEC2L, COL4A4, CSPG4, GAS7, HAPLN1, KIF24, LPL, MAP2K6, MFAP2, MYBL2, NASP, NAV1, NLGN3, PAG1, PALM2, PDGFC, RNF19A, RTKN2, SLC16A1, SOWAHC, TMEM132A, VEGFA

hsa-miR-34a-5p

miR-34a-5p (and other miRNAs w/seed GGCAGUG)

25

ABLIM1, ADCY5, ANK2, CD47, CDC25A, COL4A4, DAAM1, FAM107A, GABRA3, GLCE, INHBB, MYRIP, NAV1, NOS1, PAG1, PALM2, PTGIS, RIMS3, SDK2, SLCO3A1, SOGA1, SOX4, TMEM35, VEGFA, WHSC1

hsa-miR-361-5p

miR-361-5p (miRNAs w/seed UAUCAGA)

7

ADCY2, ERG, FOXM1, GCOM1, PEG3, VEGFA, VWDE

hsa-miR-374a-5p

miR-374b-5p (and other miRNAs w/seed UAUAAUA)

21

CD47, FAM169A, FAM19A2, GAS7, HAPLN1, HES1, HUNK, INHBB, MAP2K6, MKX, MMRN1, NR4A3, PLXNA2, RTKN2, SHANK2, SNTB1, SOX4, SPTSSB, UST, VEGFA, ZNF423

hsa-miR-503

miR-503-5p (miRNAs w/seed AGCAGCG)

14

CASR, CDC25A, CDCA4, CHEK1, CNNM3, DNAAF3, GLCE, IHH, NAV1, NOS1, PARM1, SOX5, VEGFA, ZNF423

hsa-miR-514b-5p

miR-513c-5p (and other miRNAs w/seed UCUCAAG)

2

BRCA2, PDE6A

hsa-miR-514a-3p

miR-514a-3p (and other miRNAs w/seed UUGACAC)

1

PEG3

hsa-miR-25-3p

miR-92a-3p (and other miRNAs w/seed AUUGCAC)

19

ACAN, ADGRB3, ANGPTL2, BCL11A, CHGA, CHST1, DAG1, GLCE, GRIA1, HAPLN1, HOXD10, SIK1, MARCH4, MYLIP, NR4A3, PALM2, SORL1, SOX4, SYNDIG1