Table 3 Top 10 inhibited upstream regulators of negatively correlated miRNAs and targets identified by ingenuity IPA analysis19.
From: Characterization of the miRNA regulators of the human ovulatory cascade
Upstream Regulator | Exp Log Ratio | Molecule Type | Activation z-score | p-value of overlap | Target molecules in dataset |
|---|---|---|---|---|---|
TGFB1 | growth factor | −4.118 | 5.51E-07 | ACAN, ADAMTS2, CDC25A, CSPG4, DAAM1, DAPK1, DSP, E2F1, ESPL1, ESR2, FAM107A, GAS7, GATM, GLCE, GREM1, GRIA1, GSE1, HES1, INHBB, LOXL1, LPL, MFAP2, MMP11, MYBL2, NR4A3, PDGFA, PLXNC1, PRC1, PRIM1, RAD51AP1, RAPGEF3, RASL11B, S1PR3, SEMA7A, SOX4, THBS1, TOP2A, TYMS, UST, VEGFA, ZEB1 | |
MITF | transcription regulator | −3.606 | 3.85E-07 | ACAN, AURKB, CEP55, CHAF1A, DAPK1, ECT2, ESPL1, FRMD4B, HAPLN1, HAUS8, HES1, ITPKB, SOX5, TMCC2 | |
CSF2 | cytokine | −3.448 | 1.48E-03 | CHAF1A, FOXM1, HAUS8, IFNLR1, MCM3, NUSAP1, PPIF, PRC1, RRM2, SNTB1, STMN1, THBS1, TOP2A | |
MYC | transcription regulator | −3.281 | 9.61E-04 | ACAN, AURKB, CD47, CDC25A, CHEK1, CSPG4, CTSV, DSP, E2F1, EZH2, FOXM1, HAPLN1, HES1, MSH2, PEG3, RRM2, SLC16A1, SOX5, STMN1, THBS1, THBS2, TYMS, VEGFA | |
FOXM1 | −4.219 | transcription regulator | −3.088 | 6.30E-07 | AURKB, CDC25A, ESR1, FOXM1, PDGFA, PRC1, STMN1, TOP2A, VEGFA, ZEB1 |
HGF | growth factor | −2.925 | 1.12E-03 | ANGPTL2, AURKB, CDC25A, CDC6, ENTPD1, FOXM1, HES1, NR4A3, PDGFA, PLXNA2, PRC1, THBS1, VEGFA, ZEB1 | |
SP1 | transcription regulator | −2.918 | 6.72E-03 | CHGA, E2F1, ESR1, FOXM1, GRIA1, LPL, MMP11, MYBL2, NOS1, PDGFA, PDGFC, TYMS, VEGFA | |
CCND1 | transcription regulator | −2.884 | 2.97E-07 | CDC6, CEP55, CLSPN, DDIAS, DEPDC1, DTL, E2F1, ESCO2, FOXM1, KIAA0101, MYRIP, RRM2, SOX4, TYMS, ZNF423 | |
Vegf | group | −2.834 | 3.46E-05 | ACAN, ANGPTL2, AURKB, CDC25A, CDC6, DPF3, ENTPD1, FOXM1, HES1, IHH, INHBB, NR4A3, PDGFA, PLXNA2, PRC1, VEGFA, ZEB1 | |
PTGER2 | g-protein coupled receptor | −2.828 | 1.97E-05 | CEP55, DEPDC1, ECT2, NUSAP1, PBK, PRC1, THBS1, VEGFA |
