Table 4 Top 10 activated upstream regulators of negatively correlated miRNAs and targets identified by ingenuity IPA analysis19.
From: Characterization of the miRNA regulators of the human ovulatory cascade
Upstream Regulator | Exp Log Ratio | Molecule Type | Activation z-score | p-value of overlap | Target molecules in dataset |
|---|---|---|---|---|---|
let-7 | microrna | 3.246 | 1.97E-05 | AURKB,BRCA2, CDC25A, CDC6, CHEK1, EZH2, FANCD2, MCM3, PPP1R12B, RRM2, THBS1 | |
mir-21 | 8.541619 | microrna | 3.093 | 3.46E-05 | CDC25A, DDAH1, ECT2, MSH2, NUSAP1, PBK, PRC1, RAD51AP1, STMN1, TOP2A |
RBL1 | transcription regulator | 2.923 | 3.79E-10 | AURKB, CDC25A, CDC6, E2F1, HES1, MCM3, MYBL2, RRM2, THBS1, TYMS, ZEB1 | |
CDKN2A | transcription regulator | 2.837 | 1.04E-07 | AURKB, CDC25A, CDCA4, CHAF1A, E2F1, EZH2, GAS7, HMGB2, HUNK, MYBL2, PDGFA, PEG3, RAD51AP1, RRM2, TMPO, VEGFA | |
BNIP3L | other | 2.828 | 1.48E-07 | CD47, CHEK1, E2F1, FANCD2, MYBL2, PRIM1, RRM2, TOP2A | |
miR-16-5p | 4.689 | mature microrna | 2.777 | 1.71E-03 | CDC25A, CHEK1, CRHBP, HERC6, MSH2, PPIF, PRIM1, VEGFA |
let-7a-5p | 4.174 | mature microrna | 2.768 | 2.61E-04 | AURKB, CDC25A, DSP, FANCD2, PRIM1, SLC1A4, THBS1, TYMS |
LY294002 | chemical - kinase inhibitor | 2.73 | 1.25E-03 | ACAN, BRCA2, ESR1, HAPLN1, HES1, HMGB2, INHBB, LOC102724428/SIK1, NR4A3, THBS1, TOP2A, TYMS, VEGFA, ZEB1 | |
CDKN1A | kinase | 2.605 | 4.66E-12 | AURKB, CDC25A, CDC6, CEP55, CHEK1, DTL, FANCI, FOXM1, HMGB2, KIAA0101, MCM3, MYBL2, NUSAP1, PBK, PRC1, STMN1, TOP2A, TYMS, VEGFA | |
sirolimus | chemical drug | 2.527 | 2.84E-02 | CDC25A, CHEK1, E2F1, GRIA1, NR4A3, STMN1, TMPO, TOP2A, TYMS, VEGFA |
