Table 6 Publications investigating EVs from mesenchymal stem cells.

From: Evaluation of the cardioprotective potential of extracellular vesicles – a systematic review and meta-analysis

Ref.

PM

Size

Injury model

Main effector

EV marker

Feng et al.10

UC/Precipitation

30–120 nm

MI

miR-22

CD63

X. Wang et al.9

UC, sucrose gradient

10–100 nm

Sepsis/Inflammation

miR-223

CD81, CD63

Teng et al.44

Precipitation

50–100 nm

MI

NSI

CD63

Zhang et al.46

Precipitation

11–98 nm

MI

NS

CD63, GAPDH

Zhao et al.23

UC, sucrose cushion, ultrafiltration

20–85 nm

In vitro hypoxia, MI

NSI

CD9, CD63

Kang et al.36

Precipitation

40–90 nm

MI

CXCR4

CD9, CD63

Yu et al.41

Precipitation

≈100 m*

NSI

(miR-221)

CD9, CD63, HSP70

Yu et al.42

Precipitation

≈100 nm

In vitro hypoxia, MI

miR-19a

CD9, CD63, HSP70

Lai et al.20

Size exclusion fractionation (UC sucrose gradient, Immunoprecipitation)

55–65 nm

I/R-injury

NSI

CD9, CD81, Alix

Arslan et al.50

Ultrafiltration, Chromatography

NSI

I/R-injury

NSI

NSI

Shi et al.48

Precipitation

30–100 nm

H2O2

miR-21

CD9, CD63, HSP70

  1. EV-purification method (PM), particle size, investigated injury model, main effector mediating protection and EV marker are stated. CXCR = CXC chemokine receptor; UC = ultracentrifugation; MI = myocardial infarction; I/R = ischemia/reperfusion; NSI = not specifically indicated; Ref. = reference; HSP = heat shock protein; GAPDH: glyceraldehyde 3-phosphate dehydrogenase *self-assessed (assumption made from EM images).