Table 9 Summary of all publications which investigated the protective effects of extracellular vesicles (EVs) sorted by the EV source.

From: Evaluation of the cardioprotective potential of extracellular vesicles – a systematic review and meta-analysis

EV source

Publication

Cardiac

damage

Apoptosis/cell

death

Caspase activation

Proinflammatory

mediators

LDH release/Activity

Ejection

fraction

Protective

kinases

Proliferation/Migration

Tube formation/cell survival

CPCs

Barile et al.13

X

X

X

  

X

  

X

Chen et al.34

X

X

X

      

Xiao et al.39

 

X

X

      

Gray et al.22

X

       

X

CDCs

Namazi, Namazi et al.25

 

X

X

      

Ibrahim et al.35

X

X

 

X

 

X

 

X

X

Namazi, Mohit et al.28

        

X

de Couto et al.47

X

X

 

X

 

X

 

X

 

MSCs

Feng et al.10

X

X

       

X. Wang et al.9

X

X

 

X

 

X

  

X

Kang et al.36

X

X

X

  

X

X

 

X

Teng et al.44

X

  

X

 

X

  

X

Zhang et al.46

X

    

X

 

X

X

Zhao et al.23

X

X

   

X

 

X

X

Yu et al.42

X

X

  

X

X

X

 

X

Arslan et al.50

X

  

X

 

X

X

  

Lai et al.20

X

        

Shi et al.48

 

X

X

   

X

  

Fibroblasts

Borosch et al.33

       

X

 

Cardiomyocytes

X. Wang et al.24

X

X

   

X

X

X

X

Garcia et al.21

       

X

X

Ribeiro-Rodrigues et al.30

       

X

X

Body fluids

Vicencio et al.7

X

X

    

X

  

Ma et al.15

X

        

X. Wang et al.24

X

X

   

X

   

Giricz et al.8

X

        

Davidson et al.27

 

X

    

X

  

Minghua et al.49

X

X

X

 

X

X

   

Wider et al.32

 

X

       

Other cell types

Y. Wang et al.45

X

X

X

      

Balbi et al.26

 

X

 

X

   

X

X

Kang et al.14

       

X

X

Gu et al.19

 

X

    

X

 

X

Vandergriff et al.51

X

X

   

X

   

Ong et al.38

    

X

 

X

 

X

Davidson et al.27

 

X

       
  1. The effect of EVs derived from the indicated source are indicated as follows: Indicates a reduction, indicates an elevation/activation. LDH: Lactate dehydrogenase, CPCs: cardiac progenitor cells, CDCs: cardiosphere derived cells, MSCs: mesenchymal stem cells.