Figure 4

Potency and toxicity of R430 and conventional antivirals on selected RNA and DNA viruses. A panel of antiviral drugs were incubated with cell cultures and R430, conventional antivirals or vehicle as described, in triplicate. The 50% inhibitory concentration (EC50) values are shown (upper panel). Separately, the 50% cytotoxic concentrations (CC50) were estimated following incubation of cell lines with drugs or vehicle in the absence of virus. ZIKA: Zika virus; HCV: Hepatitis C virus, HSV-2: Herpes Simplex virus, type 2; HCMV: Human cytomegalovirus; MCMV: murine cytomegalovirus; HBV: Hepatitis B virus.