Figure 5 | Scientific Reports

Figure 5

From: Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

Figure 5The alt text for this image may have been generated using AI.

Analysis of markers of HSC activation in livers from Fc-GLP-1 treated mice 2 weeks after PH. (a) Hepatic mRNA levels of HSC related genes analyzed 2 weeks after PH (n = 6 mice/group). (b,c) Representative images and quantification of α-SMA and desmin immunohistochemistry (n = 4 mice/group; 3 random fields per mice; *p = 0.018 (C+Fc-GLP-1); **p = 0.00014 (MCD) and **p = 0.00019 (M+Fc-GLP-1) and Sirius Red staining (2 fields per mice; n = 4 mice/group) at 2 weeks after PH. (d) Representative TEM images of livers from M+Fc-GLP-1 mice showing hepatic stellate cells (HSC) containing lipid droplets (LD) and collagen fibers (COL) surrounding vein (V) and quantification of HSC (4 random fields per mice; n = 3 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001 vs C group; ##p < 0.01, ###p < 0.001 vs MCD group according to one-way ANOVA with post-hoc Bonferroni test.

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