Figure 6 | Scientific Reports

Figure 6

From: Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy

Figure 6The alt text for this image may have been generated using AI.

Comparison of the microarray data of livers from Fc-GLP-1 treated mice before and after PH by GSEA software. (a) Venn diagram of gene sets up-regulated in C+Fc-GLP-1 and M+Fc-GLP-1 groups 2 weeks after PH versus values of each individual group analyzed in liver samples removed in the hepatectomy (n = 4 mice/group). (b) Gene sets commonly up-regulated in both C+Fc-GLP-1 and M+Fc-GLP-1 groups versus values analyzed in liver samples removed in the hepatectomy. (c) Principal inflammatory gene sets up-regulated in Fc-GLP-1 treated animals 2 weeks post-PH versus values obtained in liver samples removed in the hepatectomy (n = 4 mice/group). (d) mRNA levels of pro-inflammatory cytokines, cytotoxic lymphocytes and neutrophils related genes analyzed 2 weeks after PH in comparison with values of each individual group measured in liver samples removed in the hepatectomy (n = 6 mice/group). (e) Principal HSC-related gene sets up-regulated in Fc-GLP-1 treated animals as indicated above (n = 4 mice/group). (f) mRNA levels of genes related to HSC activation in Fc-GLP-1- treated animals as indicated above (n = 6 mice/group). Fold change of hepatic levels of metabolites related to activation of HSC in C+ Fc-GLP-1 (g) and M+ Fc-GLP-1 (h) under conditions indicated above (n = 6 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001 vs each group before PH according to one-way ANOVA with post-hoc Bonferroni test.

Back to article page