Figure 5 | Scientific Reports

Figure 5

From: Ionic and cellular mechanisms underlying TBX5/PITX2 insufficiency-induced atrial fibrillation: Insights from mathematical models of human atrial cells

Figure 5

Role of sarcoplasmic reticulum (SR) calcium leak (Jleak) in spontaneous depolarization generation. Simulated action potential (AP) (a), cytosolic calcium concentration [Ca2+]i (b) and calcium flow Jrel (c) through the ryanodine receptor (RyR) are displayed under control, homozygous TBX5-knockout (Hom-Tbx5) and Hom-Tbx5 with inhibition of Jleak (Hom-Tbx5-block). According to the effect of dantrolene on Jleak (d), when Jleak was inhibited by 80% (Hom-Tbx5-dantrolene), changes in APD90 (e) and triggered beats/min (f) compared to Hom-Tbx5 are shown. Simulated results were compared to the experimental data by Hartmann et al.38.

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