Table 5 Correlation between CTL escape mutations and viro-immunological parameters belonging to 781 individuals characterized by recent infection or by plasma viral load >10,000 copies/ml and CD4+T cells >500 copies/ml.

From: Genetic divergence of HIV-1 B subtype in Italy over the years 2003–2016 and impact on CTL escape prevalence

Number of CTL escapes

Plasma viral load, copies/ml, median (IQR)

P-value

CD4+T cells, cells/mm3, median (IQR)

P-value

CD4/CD8 Ratio, mean ± SE

P-value

0, N = 75

46,955 (26,054–139,500)

0.994* 0.667§

690 (536–816)

0.913* 0.912§

1.64 ± 0.68

0.034* 0.027§

1, N = 147

60,000 (21,670–223,238)

621 (535–764)

1.02 ± 0.15

2, N = 224

56,160 (23,296–170,885)

628 (542–764)

0.82 ± 0.05

3, N = 175

45,973 (162,295-125,728)

629 (539–777)

0.82 ± 0.05

4, N = 90

69,285 (24,275–262,493)

664 (560–800)

0.79 ± 0.07

≥5, N = 70

53,904 (18,213–205,785)

603 (549–695)

0.69 ± 0.05

  1. *Statistically significant differences were assessed by Kruskal-Wallis test, corrected for Benjamini-Hochberg method. §Statistically significant differences were assessed by Spearman correlation. IQR: Interquartile-range; SE: standard error.
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