Table 5 Logistic Regression Analysis of the Risk Factors Associated with the Mechanical Complication and Acute Respiratory Distress Syndrome (ARDS) among Patients with Influenza A(H1N1)pdm09 Virus Infection.

From: Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks

Variables

Mechanical Ventilation

ARDS

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Gender, male

1.1 (0.7–2.0)

0.5

  

1.5 (0.8–2.9)

0.3

  

6B/6B.1/6B.2 season

3.4 (2.1–5.6)

<0.001

2.6 (1.2–5.6)

0.02

5.0 (2.6–9.96)

<0.001

5.5 (1.9–15.9)

0.002

Age group

 

<0.001

 

0.006

 

0.02

 

0.9

   ≤5

Reference

 

Reference

 

a

a

a

a

   6–18

0.7 (0.2–2.4)

0.6

0.8 (0.2–3.4)

0.76

a

a

a

a

   19–49

3.7 (1.6–8.6)

0.002

4.0 (1.3–12.6)

0.02

Reference

 

Reference

 

   50–64

12.9 (5.4–31)

<0.001

3.9 (1.1–13.8)

0.04

2.8 (1.3–5.9)

0.007

0.8 (0.2–2.6)

0.7

   ≥65

27.9 (10.6–73.6)

<0.001

9.6 (2.3–39.6)

0.002

2.1 (0.8–5.5)

0.1

0.7 (0.16–2.9)

0.6

Onset to presentation

1.1 (1.02–1.15)

0.008

1.04 (0.96–1.13)

0.3

1.09 (1.03–1.16)

0.006

1.1 (0.98–1.25)

0.1

Underlying conditions

14.2 (8.1–24.9)

<0.001

5.5 (2.34–13.1)

<0.001

10.6 (5.2–21.4)

<0.001

2.1 (0.6–6.7)

0.2

Obesity

7.1 (3.6–14.3)

<0.001

2.4 (0.88–6.6)

0.08

11.7 (5.4–25.3)

<0.001

3.0 (1.04–8.7)

0.04

Smoking

10.8 (5.3–22.1)

<0.001

2.24 (0.7–7.3)

0.2

16.7 (7.7–36.2)

<0.001

2.9 (0.9–9.7)

0.09

Alcoholism

42.2 (4.9–367)

0.001

8.2 (0.6–109.1)

0.1

32.2 (5.7–181.6)

<0.001

3.8 (0.4–39.3)

0.27

Antiviral therapy

 

<0.001

 

0.03

 

<0.001

 

0.05

   No antiviral therapy

Reference

 

Reference

 

Reference

 

Reference

 

   Within 48 hours

8.2 (2.4–27.6)

0.001

3.4 (0.8–14.8)

0.1

12.3 (1.6–94.6)

0.02

5.2 (0.2–124.6)

0.3

   After 48 hours

25.5 (7.8–83.8)

<0.001

8.5 (2.1–33.9)

0.002

41.7 (5.6–310.5)

<0.001

13.4 (0.7–268.9)

0.09

  1. aData cannot be calculated due to absence of ARDS in the age group.