Figure 4 | Scientific Reports

Figure 4

From: Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway

Figure 4

Cleavage of ATF6 was upregulated in Ptf1a cKO mice on day 3 but recovered by day 10. (a) Western blotting of control and Ptf1a cKO mice on day 3. (b) Comparison of the ratio of total ATF6/GAPDH expression in control and Ptf1a cKO mice on day 3. (c) Comparison of the ratio of cleaved ATF6/total ATF6 expression in control and Ptf1a cKO mice on day 3. (d) Western blotting of control and Ptf1a cKO mice on day 10. (e) Comparison of the ratio of total ATF6/GAPDH expression in control and Ptf1a cKO mice on day 10. (f) Comparison of the ratio of cleaved ATF6/total ATF6 expression in control and Ptf1a cKO mice on day 10. f-ATF6: full length ATF6, c-ATF6: cleaved ATF6. control, n = 4; Ptf1a cKO, n = 4. *P < 0.05. The original, unprocessed scans of the blots are shown in Supplementary Fig. S5.

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