Table 3 Univariate and multivariate analysis of overall survival in each cohort (*, **, *** indicate significance at the <0.05, <0.01, <0.001).

From: SAC3D1: a novel prognostic marker in hepatocellular carcinoma

Parameters

Univariate analysis

Multivariate analysis

P

HR

95 Cl

P

HR

95 Cl

GSE10186

Alcohol

0.797

1.097

0.4513

1.842

—

—

—

—

Hepatitis B

0.712

1.156

0.5347

2.501

—

—

—

—

Hepatitis C

0.859

0.9341

0.4411

1.978

—

—

—

—

SAC3D1

0.00739**

2.9517

1.337

6.516

0.00695**

3.0229

1.3539

6.7490

TCGA

Age

0.189

0.9903

0.9952

1.025

—

—

—

—

Stage

(I, II vs III, IV)

3.03e-6***

2.4341

1.675

3.536

9.92e-5***

2.1853

1.4742

3.2394

Gender

(female vs male)

0.212

0.786

0.5385

1.147

—

—

—

—

Histologic grade

(G1, 2 vs G3, 4)

0.674

1.084

0.7439

1.580

—

—

—

—

SAC3D1

0.0001***

2.5158

1.578

4.011

2.89e-5***

2.7560

1.7137

4.4323

Alcohol consumption

0.691

0.9194

0.6078

1.391

—

—

—

—

Hepatitis B

4.95e-5***

0.3515

0.2121

0.5824

9.35e-5***

0.3256

0.1855

0.5717

Hepatitis C

0.628

1.136

0.6773

1.907

—

—

—

—

ICGC

Age

0.918

1.002

0.9714

1.033

—

—

—

—

Stage

(I, II vs III, IV)

0.0085**

2.249

1.23

4.111

0.012*

2.8855

1.5174

5.4869

Gender

(female vs male)

0.282*

0.4980

0.2671

0.9284

0.0053**

0.3871

0.1986

0.7543

SAC3D1

5.61e-5***

3.646

1.943

6.842

6.51e-5***

3.6307

1.9282

6.8364

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