Table 3 Factors associated with high MICA expression in the cancer.

From: Lower protein expression levels of MHC class I chain-related gene A in hepatocellular carcinoma are at high risk of recurrence after surgical resection

 

High MICA (n = 99)

Low MICA (n = 94)

P value

OR

C.I.

P value

Age (years, mean ± SD)

63.2 ± 12.1

62.3 ± 10.9

0.61

   

Male gender, n (%)

79 (79.8)

65 (69.1)

0.09

   

BMI (kg/m2, mean ± SD)

24.6 ± 3.2

25.1 ± 5.3

0.41

   

AST (IU/L, mean ± SD)

56 ± 36

55 ± 40

0.92

   

ALT (IU/L, mean ± SD)

48 ± 34

54 ± 45

0.29

   

α-fetoprotein >20 ng/mL, n (%)

42 (42.4)

41 (43.6)

0.71

   

Fibrosis stage 3–4, n (%)

54 (54.5)

50 (53.2)

0.85

   

HBV/HCV, n

44/20

43/31

0.20

   

Child-Pugh score A, n (%)

81 (81.8)

82 (91.1)

0.63

   

MICA rs2596542 A allele, n (%)*

26 (27.1)

64 (70.3)

<0.001

0.16

0.08–0.30

<0.001

BCLC stage 0-A, n (%)

59 (59.6)

58 (61.7)

0.82

   

TMN stage 1–2, n (%)

21 (21.2)

13 (13.8)

0.18

   

Tumor size >5 cm, n (%)

34 (34.3)

36 (38.3)

0.57

   

Tumor number >2, n (%)

19 (19.2)

13 (13.8)

0.32

   

Poor differentiated HCC†

27 (42.9)

21 (37.5)

0.55

   
  1. Note: high MICA expression: >30%. MICA: membrane MHC class I chain-related A. BMI: body mass index. AST: aspartate aminotransferase. ALT: alanine aminotransferase. HCC: hepatocellular carcinoma. HBV: hepatitis B virus. HCV: hepatitis C virus. BCLC: Barcelona Clinic Liver Cancer. *6 patients had indeterminate single nucleotide polymorphism. †Data available in 119 patients. OR: odds ratio. CI: confidence intervals.
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