Table 4 Factors associated with HCC recurrence.

From: Lower protein expression levels of MHC class I chain-related gene A in hepatocellular carcinoma are at high risk of recurrence after surgical resection

 

HCC recurrence (+) (n = 22)

HCC recurrence (−) (n = 149)

P value

HR

C.I.

P value

Age (years, mean ± SD)

61.9 ± 11.9

62.7 ± 11.4

0.76

   

Male gender, n (%)

20 (90.9)

110 (73.8)

0.09

   

BMI (kg/m2, mean ± SD)

23.7 ± 3.6

25.0 ± 4.6

0.22

   

AST (IU/L, mean ± SD)

61 ± 41

55 ± 37

0.49

   

ALT (IU/L, mean ± SD)

61 ± 43

51 ± 40

0.29

   

α-fetoprotein >20 ng/mL, n (%)

9 (42.9)

62 (42.8)

0.84

   

Fibrosis stage 3–4, n (%)

12 (54.5)

80 (53.7)

1

   

Child-Pugh score A, n (%)

18 (85.7)

128 (90.1)

0.45

   

MICA rs2596542 A allele, n (%)

12 (54.5)

65 (45.5)

0.30

   

Tumor MICA expression* <30%, n (%)

15 (68.2)

71 (47.7)

0.04

2.77

1.07–7.14

0.035

BCLC stage 0-A, n (%)

7 (31.8)

101 (67.8)

<0.001

   

TMN stage 1, n (%)

3 (13.6)

60 (40.3)

0.01

   

Tumor size >5 cm, n (%)

15 (68.2)

44 (29.5)

<0.001

5.22

2.11–12.96

<0.001

Tumor number >2, n (%)

5 (22.7)

22 (14.8)

0.32

   
  1. Note: MICA: MHC class I chain-related A. BMI: body mass index. AST: aspartate aminotransferase. ALT: alanine aminotransferase. BCLC: Barcelona Clinic Liver Cancer. HR: hazard ratio. CI: confidence intervals. *Tumor part.
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