Figure 8 | Scientific Reports

Figure 8

From: Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson’s disease

Figure 8

DA-9805 normalized the mRNA levels of mitochondria OXPHOS subunits in the SNpc and the striatum in an MPTP-induced subacute PD model mice. Analysis of mitochondria OXPHOS subunits via real-time quantitative PCR (qRT-PCR). Mice were orally administered DA-9805 (10 or 20 mg/kg), reference drug (0.05 mg/kg rasagiline), or 3% HPMC vehicle for 12 days. On day 8, MPTP was injected intraperitoneally for five days (30 mg/kg, 24-h interval). The substantia nigra pars compacta (SNpc) and the striatum (ST) were dissected from each brain and analyzed via qRT-PCR. (a) mtDNA-encoded OXPHOS subunits. (b) Nuclear DNA-encoded OXPHOS subunits and tyrosine hydroxylase (TH). The data are presented as the mean ± SEM (n = 7). #p < 0.05, ##p < 0.01, ###p < 0.001 vs. Normal; *p < 0.05, **p < 0.01, and ***p < 0.001 vs. MPTP-treated vehicle control. p values are from a one-way ANOVA followed by Tukey’s test.

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