Figure 2
From: Reversal of cerebrovascular constriction in experimental cerebral malaria by L-arginine
(A–E) Pial arteriolar diameter responses to L-arginine treatment, given intravenously as a bolus injection, in ECM mice. Each graph represent the responses to different dosages: (A) none (saline); (B) 10 mg/kg; (C) 50 mg/kg; (D) 100 mg/kg; (E) 200 mg/kg. Four mice were investigated in each dosage group. Each circle represents an individual arteriole (total number per group varied between 14 and 30). Diameter changes are presented relative (%) to their healthy baseline at day 0 prior to infection (dotted line). An asterisk (*) represents a significant increase (p < 0.05) in diameter in relation to time zero (“Pre”), whereas a hashtag (#) represents a significant decrease (p < 0.05) in diameter. (F) Pial arteriolar diameter responses to L-arginine treatment, given intravenously as a bolus injection, in uninfected control mice. The bars represent the mean ± standard deviation of % diameter change of each group (saline or L-arginine 10, 50, 100 and 200 mg/kg) relative to pre-treatment.
