Figure 3
From: Reversal of cerebrovascular constriction in experimental cerebral malaria by L-arginine
Pial arteriolar diameter responses to L-arginine treatment, given intravenously as a bolus injection, in ECM mice. The bars represent the mean ± standard deviation of % diameter change of each group (saline or L-arginine 10, 50, 100 and 200 mg/kg), in this case relative to pre-treatment (baseline defined as the arteriolar diameters of mice with ECM on day 6, just before treatment). (A) Mean ± standard deviation of % diameter change of individual vessels. (B) Mean ± standard deviation of % diameter change of individual animals (vessel diameter changes averaged per animal). ECM mice that received saline showed aggravation of vasoconstriction over time (1 h, 3 h, 6 h and 24 h). L-arginine prevented the aggravation of vasoconstriction (at all doses) and even resulted in dilation (doses of 50, 100 and 200 mg/kg). The changes in diameter were significantly different from the saline group for all doses at the timepoints of 1 h, 3 h and 6 h (A) (10 mg/kg: p = 0.0097; 50 mg/kg: p = 0.0018; 100 mg/kg: p = 0.0001; 200 mg/kg: p < 0.0001) and for all doses except 10 mg/kg in (B) (10 mg/kg: p = 0.1072; 50 mg/kg: p = 0.0435; 100 mg/kg: p = 0.01; 200 mg/kg: p < 0.0186).
