Figure 4
From: Reversal of cerebrovascular constriction in experimental cerebral malaria by L-arginine
(A–C) Pial arteriolar diameter responses to slow continuous delivery of L-arginine (50 mg/kg/day) given subcutaneously using osmotic pumps, in uninfected (A) and ECM mice receiving saline (B) or L-arginine (C). Three to four mice were investigated in each group (A: 24 arterioles, B: 14 arterioles, C: 21 arterioles). For uninfected healthy mice, diameter changes are presented with respect to their pre-treatment levels, whereas for infected ECM mice diameter changes are presented with respect to their healthy baseline at day 0 prior to infection. One mouse died in group C after timepoint 6 hours. An asterisk (*) represents a significant increase (p < 0.05) in diameter in relation to time zero, whereas a hashtag (#) represents a significant decrease (p < 0.05) in diameter in relation to time zero. (D) Mean ± standard deviation of % diameter change of each group (saline or L-arginine 50 mg/kg/h), in this case relative to pre-treatment (baseline defined as the arteriolar diameters of mice with ECM on day 6, just before treatment). The changes in diameter in the L-arginine group were significantly different from the saline group at the timepoints of 1 h, 3 h and 6 h (p = 0.007).
